All functions

CamConfig()

Set CAMDAC configuration

CamSample()

Build CAMDAC sample object

LogR_correction()

LogR_correction

annotate_copy_number()

Assign copy number calls

ascat.m.plotRawData()

ascat.m.plotRawData

ascat.m.plotSegmentedData()

ascat.m.plotSegmentedData

asm_pipeline()

Run allele-specific methylation analysis pipeline

attach_output()

Manually assign output file to CAMDAC sample

bin_CpGs()

Cluster CpGs into annotated bins

cmain_bind_snps()

Bind SNPs

cmain_call_cna()

Call CNA

cmain_call_dmps()

Call tumour-normal DMPs

cmain_call_dmrs()

Call tumour-normal DMRs

cmain_count_alleles()

Count alleles

cmain_deconvolve_methylation()

Deconvolve methylation

cmain_make_methylation_profile()

Make methylation

cmain_make_snps()

Make SNPs

cmain_run_ascat()

Run ASCAT.m

cmain_run_battenberg()

Run battenberg

compute_tumour_methylome()

Compute the tumour methylation rate

cwrap_asm_get_allele_counts()

Count alleles for reads phased to SNPs in a BAM file

download_pipeline_files()

Download CAMDAC pipeline files

format_methylation_df()

Format methylation rates format_methylation_df

format_output()

Format output nucleotide counts format_output

get_DMPs()

Get DMPs

get_DMRs()

Assign bins

get_allele_counts()

Compile allele counts at SNPs and at CpGs for bisulfite sequencing data get_allele_counts

get_differential_methylation()

Perform differential methylation analysis on deconvolute tumour methylation rates

get_msp1_fragments()

get_msp1_fragments

get_pure_tumour_methylation()

Deconvolve the pure tumour methylation rate from bisulfite sequencing data

get_reference_files()

Get CAMDAC reference files from config

intervalWidth()

@param ICDFname is R's name for the inverse cumulative density function of the distribution.

load_cna_data()

Parse ASCAT and bb output directories to load CNA data

load_panel_ac_files()

Load allele count files

panel_asm_from_counts()

Panel ASM from counts Basic function to create an ASM methylation panel from allele count or ASM meth files WARNING: In active development.

panel_meth_from_beta()

Make CAMDAC methylation panel from a matrix of beta values

panel_meth_from_counts()

Make CAMDAC methylation panel from allele counts Methylation fractions are obtained by summing M and UM reads across samples

pipeline()

CAMDAC tumor-normal pipeline

pipeline_tumor_normal()

Call CAMDAC for a tumor and patient-matched normal sample

plot_BAF_and_LogR()

Plot BAF and logR profiles with ggplot

plot_SNP_info()

Plot SNP data summary and QC

plot_methylation_info()

Plot Methylation

plot_normal_SNP_info()

Plot plots SNP QC

preprocess()

Preprocess a list of CamSample objects for analysis

preprocess_asm()

Preprocess a list of CamSample objects for ASM analysis

remove_low_cov_singletons()

remove_low_cov_singletons

run_ASCAT.m()

Obtain allele-specific copy number profiles, tumour purity and plot SNP data

run_methylation_data_processing()

Filter bulk tumour and normal methylation data, get methylation rate highest density interval (HDI) and plot raw methylation info run_methylation_data_processing

sort_genomic_dt()

Sort a data table with genomic coordinates